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Moreover, patients were stratified based on their clinical evolution in asymptomatic (not requiring hospitalization), patients with mild disease (defined by a total time in hospital lower than 10 days), patients with severe disease (defined by a total time in hospital over 20 days and/or admission at the ICU) and patients with fatal outcome or deceased

ZamoranoJLLancellottiPMunozDRAboyansVAsteggianoRGalderisiMet al

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Bufalin, a compound found in Chinese herbal medicine chansu , has the ability to interact with NF-B binding

These exciting findings indicate that polyP has a dual effect on mPTP activitypromoting the transient opening of Ca 2+-induced mPTP opening which can prevent mitochondria from Ca 2+ overload